Fenilin relates to agents that affect blood clotting, indirect anticoagulants. It causes hypoprothrombinemia due to violation of the process of formation of prothrombin in the liver, and also reduces the formation factors. fenilina cumulated effect more than neodikumarina. At intake reduction in the concentration of clotting factors occurs within 8-10 hours after ingestion fenilina and reaches a maximum after 24-30 hours. After oral administration, rapidly and almost completely absorbed. Passes histo-hematic barrier and accumulate in tissues. It is make boldenone acetate metabolized in the liver. Provided kidneys in unchanged form and as metabolites.
Prevention and treatment of thrombosis, thrombophlebitis, thromboembolic complications of myocardial infarction, embolic (but not bleeding!) Stroke, embolic lesions of various organs; for the prevention of thrombosis in the postoperative period.
Contraindications baseline prothrombin below 70%, with haemorrhagic diathesis and other diseases, which are accompanied by a decrease in blood clotting, and increased vascular permeability, pregnancy (I term), violations of the liver and kidneys, malignant tumors, ulcerous diseases of the gastrointestinal tract, pericarditis. Do not assign fenilin during menstruation (stop taking the drug for 2 days before the onset of menstruation) and in the first days after birth. With caution is prescribed for pulmonary embolism (including cancer), the elderly.
Dosing and Administration
The drug is prescribed inside. The first day of taking a daily dose of 0,12-0,18 g (in 3-4 hours), on the second day – 0,09-0,15 g daily dose in subsequent days – under 0,03- 0 06 g per day depending on the level of prothrombin in the blood (prothrombin index maintained in the range 50-40%). Higher dose for adults inside: single – 0.05 grams daily – 0,2 g
for prevention of thromboembolic complications appoint 0.03 g 1-2 times a day.
In case of acute thrombosis fenilin administered together with heparin. Fenilinom Treatment is carried out under the strict supervision of a physician with the obligatory systematic study of blood prothrombin and other clotting factors. Discontinuation of treatment should be carried out gradually.
Can cause allergic reactions (dermatitis, fever), diarrhea, nausea, hepatitis. There may be headache, fever, inhibition of bone marrow hematopoiesis, with prolonged use – micro make boldenone acetate and gross hematuria. Some patients have hands orange staining and urine – in pink. Occasionally fenilin can cause bleeding.
Possible effects described in paragraph. Side effect . Antagonist in overdose fenilina is vitamin C. In these cases, you must stop taking the drug immediately and start introducing vikasola intramuscularly (1-2 ml of a 1% solution 3 times a day), vitamin E or assign rutin, ascorbic acid, calcium chloride. According to the testimony spend transfusion of fresh blood in the odnogruppnoy gemosta-tic doses (75-100 ml).
Interaction with other drugs
With simultaneous use of heparin, salicylates, sulfonamides, Qi metidinom noted increased anticoagulant effect. Enhances the effects of anabolic steroids, azathioprine, allopurinol, amiodarone, narcotic analgesics, androgens, antibiotics, tricyclic antidepressants, oxidizing urine means gluco-corticosteroids, diazoxide, disopyramide, isoniazid, nalidixic acid, klofib-rat, metronidazole, paracetamol, reserpine, salt solutions, alpha-tocopherol, phenylbutazone, disulfiram, quinidine, cyclophosphamide, thyroid hormones.
Propranolol, alkalizing agents urine, vitamin K, ascorbic acid, anta-tsidy, phenazone, barbiturates, haloperidol, diuretics, carbamazepine, oral contraceptives, meprotan, rifampicin, cholestyramine weaken the effect phenindione.
Treatment make boldenone acetate should be under close medical supervision with the obligatory systematic study of blood prothrombin and other coagulation factors. Systematically carried out the general analysis of urine for the early detection of hematuria.
Some patients have hands orange staining and urine – in pink, which is associated with the metabolism of fenilina and poses no danger.