No serious violations were reported in overdose. Symptoms that may occur in overdose:. Nausea, vomiting, spotting or metrorrhagia
no specific antidote, symptomatic treatment boldenone acetate for sale should be conducted.
Interactions of oral contraceptives with other drugs may lead to breakthrough bleeding and / or reduce the contraceptive reliability. It reported in the literature for the following types of interaction. Effect on hepatic metabolism : use of drugs that induce hepatic microsomal enzymes which may lead to increased clearance of sex hormones. These medicines include: phenytoin, barbiturates, primidone, carbamazepine, rifampicin; also has assumptions regarding oxcarbazepine, topiramate, felbamate, ritonavir and griseofulvin and preparations containing. Effect on enterohepatic circulation : According to separate studies, some antibiotics (e.g., penicillin and tetracycline) may reduce kishechnopechenochnuyu circulating estrogens, thereby lowering the concentration of ethinyl estradiol. during reception drugs affecting microsomal enzymes and for 28 days after their removal should additionally use a barrier method of contraception. during reception antibiotics (such as ampicillin and tetracycline) and for 7 days after their removal should be further use a barrier method of contraception. If the period of use of barrier methods of protection ends later than Bean in a package, you need to go to the next package Femoden without the usual break in receiving pills. Combination oral contraceptives may affect the metabolism of other drugs which leads to a change in their concentration in the plasma and tissues.
If any of the conditions / risk factors mentioned below are currently available, you should carefully weigh the potential risks and expected benefits of the use of combined oral contraceptives in each individual case and discussed with the woman before she decides to start taking drug. In the case of aggravation, or amplification of the first manifestations of any of these conditions or risk factors, the woman should consult with your doctor, who can decide whether to cancel the drug.
- Diseases of the cardiovascular system
There is evidence of increasing incidence of venous and arterial thrombosis and thromboembolism (such as deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke) when taking combined oral contraceptives.
The risk of developing venous thromboembolism boldenone acetate for sale is greatest in the first year of receiving such drugs. The approximate incidence in women taking low-dose oral contraceptives is up to 4 per 10,000 person-years compared to 0.5 – 3 per 10,000 person-years among women not using . The incidence of amid pregnancy is 6 per 10,000 person-years.
The risk of thrombosis (venous and / or arterial) and thromboembolism is increased:
– smokers (with the number of cigarettes or increasing age further risk increases, especially in women older than 35 years),
in the presence of:
– family history (ie venous or arterial thromboembolism ever in close relatives or parents at a relatively young age); in the case of hereditary predisposition, the woman should be assessed and the appropriate specialist to resolve the question of the possibility of using combined oral contraceptives;
– obesity boldenone acetate for sale;
– disease of the heart valves;
– atrial fibrillation;
– prolonged immobilization, major surgery, any surgery to the legs, or major trauma. In these situations, it is desirable to discontinue the use of combined oral contraceptives (in case the intended operation of at least four weeks prior to it) and not to resume reception within two weeks after the immobilization.
A possible role of varicose veins and superficial thrombophlebitis venous development thromboembolism remains controversial. It is necessary to take into account the increased risk of thromboembolism during the postpartum period.
Peripheral circulatory disorders also may occur in diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel disease boldenone acetate for sale and sickle cell disease.
The increase in the frequency and severity migraine during the use of combined oral contraceptives (which may be preceded by a cerebrovascular accident) may be a reason for immediate discontinuation of these drugs.