Absorption of the drug is high, penetrates well into all tissues of the body and the blood-brain barrier . In about 0.1% of brain tissue enters the administered dose of the drug, with the young and the elderly to a greater extent. Evenly distributed in the liver and kidneys. It is metabolized in the liver -80-95%, the pharmacologically inactive metabolites. Do not cumulated. After 3 chasa kidney begins to stand out, with the concentration in brain tissue and does not exhibit reduced in the brain for a further 6 hours. Approximately 5% is excreted by the kidneys unchanged, partly in the bile.
Indications for use.
Asthenic and anxiety and neurotic states, worry, anxiety, fear; in children with stuttering and tics; in the elderly – insomnia; for 1000 mg boldenone acetate the prevention of anxiety disorders that arise before surgery and painful diagnostic studies. In the complex treatment of alcoholism and for the relief of psychopathological disorders in somatovegetativnyh withdrawal syndrome. In combination with detoxication preparation means can be used to treat predelirioznyh states in alcoholism.
Meniere’s disease, vertigo associated with dysfunction of the vestibular apparatus of various origins; for the prevention of motion sickness when kinetoses.
Hypersensitivity of pregnancy (1 trimester), breastfeeding, children under 2 years of age.
With caution in patients with erosive and ulcerative lesions of the gastrointestinal tract, liver failure.
Dosage and administration.
Inside after eating 2-3-week 1000 mg boldenone acetate course. Adults: 250-500 mg 3 times a day. If necessary, after the daily dose increased up to 2500 mg. Children from 2 to 8 years – 50-100 mg; 8 to 14 – 250 mg 3 times a day. The single maximum dose in adults is 750 mg in patients over age 60 -500 mg, for children up to 8 years – 150 mg, from 8 to 14 years -. 250 mg
To treat alcohol withdrawal is prescribed in the first few days of treatment on day 250 500 mg 3 times daily and at bedtime to 750 mg, with a gradual decrease in the daily dose to normal adult.
for the treatment of vertigo when dysfunction of the vestibular apparatus, and Meniere’s disease appoint 250 mg 3 times daily for 14 days.
take in order to prevent sickness a dose of 250-500 mg once daily for 1 hour before starting pitching, or at the first light of seasickness symptoms. Antiseasick action tablets Phenibut increases with increasing dose. When the express manifestation of motion sickness (vomiting, etc.) pills Phenibut inside ineffective even at doses of 750-1000 mg.
Drowsiness, nausea. Increased irritability, agitation, anxiety, dizziness, headache (with the first receptions), allergic reactions (rash, pruritus).
Increased symptoms of side 1000 mg boldenone acetate effects: severe drowsiness, nausea, vomiting, hepatic steatosis (receiving more than 7 g), eosinophilia, decreased blood pressure, renal function. First aid – gastric lavage, activated charcoal and symptomatic therapy.
Interaction with other medicinal products.
For the purposes of mutual potentiation of drug Phenibut can be combined with other psychotropic drugs, reducing the dose Phenibut and match them with drugs. It extends and enhances the effects of sleeping pills, narcotic, antipsychotic and anticonvulsant drugs, and alcohol. There is evidence of increased under the influence of the drug Phenibut action anti-Parkinsonian agents.